Young animals treated with commonly-prescribed drugs develop behavioral abnormalities in adulthood say researchers at Georgetown University Medical Center. The drugs tested include those used to treat epilepsy, mood disorders and pain.
GUMC neuroscientists and others have previously shown that neurons die after these drugs are administered to immature preclinical animal models. They say the regions of the brain where this drug-induced cell death takes place are important in the regulation of mood, cognition, and movement. In the research presented at the 39th annual meeting of the Society for Neuroscience, the scientists examined if behavioral function would be affected by the drugs.
Using behavioral tests to detect characteristics of autism and schizophrenia, the researchers found that when given to infant rats, the drugs caused behavioral abnormalities later in life. What’s more, the abnormalities were not limited to the drugs known to cause neuronal cell death.
"That is of particular concern because some of the drugs may predispose to psychiatric disorders later in life,” says lead author Patrick Forcelli, a graduate student in the Interdisciplinary Program in Neuroscience at GUMC. “At the same time, our studies identify specific drugs that cause little or no long-term behavioral impairment.” Forcelli says additional research will help physicians to better select drugs to treat epilepsy, mood disorders or pain in infants and pregnant women.
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The study was funded by grants from the National Institutes of Health and with a research award from GlaxoSmithKline and a Fellowship from the Epilepsy Foundation. The authors report no related financial interests.
About Georgetown University Medical Center
Georgetown University Medical Center is an internationally recognized academic medical center with a three-part mission of research, teaching and patient care (through Georgetown’s affiliation with MedStar Health). GUMC’s mission is carried out with a strong emphasis on public service and a dedication to the Catholic, Jesuit principle of cura personalis—or “care of the whole person.” The Medical Center includes the School of Medicine and the School of Nursing and Health Studies, both nationally ranked, the world-renowned Lombardi Comprehensive Cancer Center and the Biomedical Graduate Research Organization (BGRO), home to 60 percent of the university’s sponsored research funding.
Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
